Stephen is a senior clinician/executive with twelve years Board level experience of major health and academic organisations including seven years at Imperial College Healthcare NHS Trust and Imperial College London.

He currently serves on the Board of Great Ormond Street Hospital, where he is Chair of the Quality and Safety Committee, Netscientific PLC (a FTSE 250 health technology company), Cochrane Innovations Ltd and United Medicine and a Trustee of Pancreatic Cancer UK, as the Chair of the Scientific Advisory Board.

HSJ listed Professor Smith in its 2009 rankings of the top 30 most powerful people in NHS management policy and practice in England.